Scientific Literature

Saltzman DA, Heise CP, Hasz DE, Vigdorovich V, Curtiss III RE, Kelly SM, Anderson PM, and Leonard AS: Anti-tumor Mechanisms of Attenuated Salmonella typhimurium Containing the Gene for Human Interleukin-2: A Novel Antitumor Agent. Journal of Pediatric Surgery 31(6):812–814, 1996.

Saltzman DA, Katsanis E, Heise CP, Hasz DE, Vigdorovich V, Curtiss III RE, Kelly SM, Anderson PM, and Leonard AS: Hepatic and Splenic Colonization of Attenuated Salmonella typhimurium Containing the Gene for Human Interleukin-2: A Novel Anti-Tumor Agent. Journal of Pediatric Surgery 32(2):301–306, 1997.

Saltzman DA, Katsanis E, Heise CP, Hasz DE, Vigdorovich V, Curtiss III RE, Kelly SM, Anderson PM, and Leonard AS: Antitumor Mechanisms of Attenuated Salmonella typhimurium Containing the Gene for Human Interleukin-2: A Novel Antitumor Agent. Cancer Biotherapy & Radiopharmaceuticals 12(1):37–45, 1997.

Saltzman DA, Katsanis E, Heise CP, Hasz DE, Vigdorovich V, Curtiss III RE, Kelly SM, Anderson PM, and Leonard AS: Attenuated Salmonella typhimurium Containing Interleukin-2 Decreases MC-38 Hepatic Metastases: A Novel Anti-tumor Agent. Cancer Biotherapy & Radiopharmaceuticals 12(6):379–387, 1997.

Saltzman DA, Katsanis E, Heise CP, Hasz DE, Vigdorovich V, Curtiss III RE, Kelly SM, Anderson PM, and Leonard AS: Safety and Immunogenicity of Salmonella typhimurium Expressing C-terminal Truncated Human IL-2 in a Murine Model. Vaccine 15(17-18):1823–1827, 1997.

Saltzman DA, Heise CP, Hasz DE, Vigdorovich V, Curtiss III RE, Kelly SM, Anderson PM, and Leonard AS: Hybrid Hepatitis B Virus Core-Pre-S Proteins Synthesized in Avirulent Salmonella typhimurium and Salmonella typhi for Oral Vaccination. Infection and Immunity 65(8):3381–3385, 1997.

Soto LJ, Sorenson BS, Kim AS, Feltis BA, Leonard AS, and Saltzman DA: Attenuated Salmonella typhimurium Prevents the Establishment of Unresectable Hepatic Metastases and Improves Survival in a Murine Model. Journal of Pediatric Surgery 38(4):534–537, 2003.

Sorenson BS, Banton KL, Frykman NL, Leonard AS, and Saltzman DA: Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma. Journal of Pediatric Surgery 43(6):1153–1158, 2008.

Sorenson BS, Banton KL, Frykman NL, Leonard AS, and Saltzman DA: Attenuated Salmonella typhimurium with Interleukin 2 Gene Prevents the Establishment of Pulmonary Metastases in a Model of Osteosarcoma. Journal of Pediatric Surgery 44(8):1562–1568, 2009.

Banton KL, Frykman NL, Sorenson BS, Leonard AS, and Saltzman DA: Liver and Circulating NK1.1+CD3− Cells Are Increased in Infection with Attenuated Salmonella typhimurium and Are Associated with Reduced Tumor in Murine Liver Cancer. Journal of Pediatric Surgery 45(1):176–182, 2010.

Frykman NL, Banton KL, Sorenson BS, Leonard AS, and Saltzman DA: Cyclooxygenase-2 Inhibition Augments the Hepatic Antitumor Effect of Oral Salmonella Typhimurium in a Model of Mouse Metastatic Colon Cancer. Journal of Pediatric Surgery 45(1):169–175, 2010.

Mertensotto MJ, Augustin LB, Schottel JL, and Saltzman DA: Attenuated Salmonella enterica Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer Model. Journal of Pediatric Surgery 50(5):792–797, 2015.

Mertensotto MJ, Augustin LB, Schottel JL, and Saltzman DA: Antioxidant Oils and Salmonella enterica Typhimurium Reduce Tumor in an Experimental Model of Hepatic Metastasis. Journal of Pediatric Surgery 52(6):1000–1005, 2017.

Forbes NS: Engineering the Perfect (Bacterial) Cancer Therapy. Nature Reviews Cancer 10(11):785–794, 2010. [Potent and Tumor-Specific: Arming Bacteria with Therapeutic Proteins]

Bacteria — Prospective Savior in Battle Against Cancer. Cancer Biology & Therapy, 2018.

White Paper on Microbial Anti-Cancer Therapy. 2018.

Now You See Me, Now You Don't — The Interaction of Salmonella with Innate Immune Receptors. Frontiers in Immunology, 2019.

A Phase I Clinical Study to Evaluate Safety of Orally Administered, Genetically Engineered Salmonella enterica Serovar Typhimurium for Canine Osteosarcoma. Veterinary and Comparative Oncology, 2021.

Overall Survival Following Resection of Pancreatic Ductal Adenocarcinoma (PDAC). Journal of Gastrointestinal Surgery, 2022.

Saltzman DA, Augustin LB, Schottel JL, et al.: Saltikva (Salmonella-IL2) — Preclinical and Clinical Summary. Internal Report, August 2022.

Orally Administered Multiple-Dose Saltikva (Salmonella-IL2) in Conjunction with FOLFIRINOX in a Patient with Stage IV Pancreatic Cancer: A Case Report. Clinical Oncology Case Reports, 2023.

Kavan P, Saltzman DA, Muegge J, Moradian J, and Batist G: Addition of Salmonella-IL2 to FOLFIRINOX for Metastatic Stage 4 Pancreatic Cancer Nearly Doubles Median Survival [abstract]. Proceedings of the American Association for Cancer Research Annual Meeting 2023; Cancer Res 2023;83(8_Suppl):Abstract nr CT035.

Saltzman D, Kavan P, Augustin L, Schottel J, Moradian J, Lee JT, Moradian E, and Batist G: Influence of Salmonella-IL2 in Combination with FOLFIRINOX on Overall and Progression-Free Survival in Stage IV Metastatic Pancreatic Cancer. JCO 43, 2571–2571 (2025). DOI: 10.1200/JCO.2025.43.16_suppl.2571.

Heise CP, Saltzman DA, Kelly SM, Curtis III RE, and Anderson PM: Salmonella typhimurium — A Unique Vector for the Delivery of Interleukin-2 Increases NK Activity. Poster, American Association of Cancer Researchers, San Francisco, CA, 1994.

Saltzman DA, et al.: The Attenuated Salmonella Vector (ASV) for IL2: A New and Innovative Cancer Treatment Modality. Oral Presentation, University of Minnesota Surgical Residents Association, Minneapolis, MN, 1994.

Saltzman DA, et al.: The Attenuated Salmonella Vector (ASV) for IL2: A New and Innovative Cancer Treatment Modality. Oral Presentation, Association for Academic Surgery, Albuquerque, NM, 1994.

Saltzman DA, et al.: The Attenuated Salmonella Vector (ASV) for IL2: A New and Innovative Cancer Treatment Modality. Oral Presentation, Minnesota Surgical Society, Minneapolis, MN, 1994.

Saltzman DA, et al.: Hepatic and Splenic Colonization for the Attenuated Salmonella typhimurium Containing the Gene for Human Interleukin-2: A Novel Anti-Tumor Agent. Surgical Infection Society, Milwaukee, WI, April 1996.

Saltzman DA, et al.: Anti-tumor Mechanisms of Attenuated Salmonella typhimurium Containing the Gene for Human Interleukin-2. American Pediatric Surgical Association, San Diego, CA, May 1996.

Saltzman DA, et al.: Anti-tumor Mechanisms of Attenuated Salmonella typhimurium Containing the Gene for Human Interleukin-2. Minnesota Surgical Residents Association Meeting, 1996.

Soto LJ, et al.: Attenuated Salmonella typhimurium Prevents the Establishment of Hepatic Colorectal Metastases and Improves Survival in a Murine Model. 30th Meeting of the International Society for Oncodevelopmental Biology and Medicine, Boston, MA, 2002.

Soto LJ, et al.: Attenuated Salmonella typhimurium Prevents the Establishment of Unresectable Hepatic Metastases and Improves Survival in a Murine Model. Annual Meeting, American Pediatric Surgical Association, 2002.

Saltzman DA: Attenuated Salmonella for Cancer Therapy. Invited Speaker, University of Minnesota Cancer Center, 2009.

Saltzman DA: Making Friends with an Enemy: Salmonella for Cancer Therapy. TEDx Talk, Carleton College, September 2013.

Saltzman DA: Genetically Modified Salmonella for Cancer Therapy. Annual Meeting of Life Science Alley, 2015.

Saltzman DA: Project Stealth: Genetically Modified Salmonella for Cancer Therapy. Keynote Address, Annual Meeting of Life Science Alley Association, 2016.

Saltzman DA: Genetically Modified Salmonella for Cancer Therapy. Invited Speaker, NCI Consensus Conference on Bacterial Therapy for Cancer, July 2017.

Saltzman DA, Augustin L, Leonard A, Mertensotto M, and Schottel J: Low Dose Chemotherapy Combined with Attenuated Salmonella Significantly Reduces Tumor Burden and is Less Toxic than High Dose Chemotherapy in an Autochthonous Murine Model of Breast Cancer. Central Surgical Society Annual Meeting, 2017.

Kavan P, Saltzman DA, Muegge J, Moradian J, and Batist G: Addition of Salmonella-IL2 to FOLFIRINOX for Metastatic Stage 4 Pancreatic Cancer Nearly Doubles Median Survival [abstract]. AACR Annual Meeting 2023, Orlando, FL. Cancer Res 2023;83(8_Suppl):Abstract nr CT035.

Saltzman D, Kavan P, Augustin L, Schottel J, Moradian J, Lee JT, Moradian E, and Batist G: Influence of Salmonella-IL2 in Combination with FOLFIRINOX on Overall and Progression-Free Survival in Stage IV Metastatic Pancreatic Cancer. JCO 43, 2571–2571 (2025). DOI: 10.1200/JCO.2025.43.16_suppl.2571.