FDA Fast Track designation for Saltikva® in combination with FOLFIRINOX to improve overall survival in metastatic pancreatic cancerU.S. FDA, grant of Fast Track designation · 2022

FDA

2022

FDA Orphan Drug Designation for Saltikva® for the treatment of pancreatic cancerU.S. FDA Office of Orphan Products Development · designated 17 May 2022

FDA ↗2020

Orally Administered Multiple Dose Saltikva (Salmonella-IL2) in Conjunction with FOLFIRINOX in a Patient with Stage IV Pancreatic Cancer: A Case ReportBatist G, Park J, et al. · Clinical Oncology: Case Reports 2020

Paper ↗2018

White paper on microbial anti-cancer therapy and preventionForbes NS, Coffin RS, Deng L, … Moradian E, … Saltzman DA, et al. · Journal for ImmunoTherapy of Cancer 2018;6:78

Paper ↗2016

A phase I clinical study to evaluate safety of orally administered, genetically engineered Salmonella enterica serovar Typhimurium for canine osteosarcomaFritz SE, Henson MS, Greengard E, … Modiano JF, Saltzman DA · Veterinary Medicine and Science 2016;2(3):179–190

Paper ↗2015

Attenuated Salmonella enterica Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer ModelDrees JJ, Mertensotto MJ, Liu G, Panyam J, Leonard AS, Augustin LB, Schottel JL, Saltzman DA · Anticancer Research 2015;35(2):843–850

Paper ↗2011

Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepatic metastasisSorenson BS, Banton KL, Augustin LB, Leonard AS, Saltzman DA · OncoTargets and Therapy 2011;4:53–61

Paper ↗2010

Safety and immunogenicity of Salmonella typhimurium expressing C-terminal truncated human IL-2 in a murine modelSorenson BS, Banton KL, Frykman NL, Leonard AS, Saltzman DA · Biologics: Targets & Therapy 2010;4:61–73

Paper ↗2008

Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine OsteosarcomaSorenson BS, Banton KL, Frykman NL, Leonard AS, Saltzman DA · Clinical Orthopaedics and Related Research 2008;466(6):1285–1291

Paper ↗2008

Attenuated Salmonella typhimurium with interleukin 2 gene prevents the establishment of pulmonary metastases in a model of osteosarcomaSorenson BS, Banton KL, Frykman NL, Leonard AS, Saltzman DA · Journal of Pediatric Surgery 2008;43(6):1153–1158

Paper ↗2003

Attenuated Salmonella typhimurium prevents the establishment of unresectable hepatic metastases and improves survival in a murine modelSoto LJ III, Sorenson BS, Kim AS, Feltis BA, Leonard AS, Saltzman DA · Journal of Pediatric Surgery 2003;38(7):1075–1081

Paper ↗2002

Liver and Circulating NK1.1⁺CD3⁻ Cells Are Increased in Infection with Attenuated Salmonella typhimurium and Are Associated with Reduced Tumor in Murine Liver CancerFeltis BA, Miller JS, Sahar DA, Kim AS, Saltzman DA, Leonard AS, Wells CL, Sielaff TD · Journal of Surgical Research 2002;107(1):101–107

Paper ↗2002

Cyclooxygenase-2 Inhibition Augments the Hepatic Antitumor Effect of Oral Salmonella Typhimurium in a Model of Mouse Metastatic Colon CancerFeltis BA, Sahar DA, Kim AS, Saltzman DA, Leonard AS, Sielaff TD · Journal of Gastrointestinal Surgery 2002

Paper ↗1996

Antitumor mechanisms of attenuated Salmonella typhimurium containing the gene for human interleukin-2: A novel antitumor agent?Saltzman DA, Katsanis E, Heise CP, Hasz DE, Vigdorovich V, Kelly SM, Curtiss R III, Leonard AS, Anderson PM · Journal of Pediatric Surgery 1996;31(2):301–306

Paper ↗1996

Attenuated Salmonella typhimurium containing interleukin-2 decreases MC-38 hepatic metastases: A novel anti-tumor agentSaltzman DA, Heise CP, Hasz DE, Zebede M, Kelly SM, Curtiss R III, Leonard AS, Anderson PM · Cancer Biotherapy & Radiopharmaceuticals 1996;11(2):145–153

Paper ↗

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