Some of our scientific publications

• 2026

  A phase 2 study of orally administered live biotherapeutic Salmonella-IL2 with FOLFIRINOX for stage IV pancreatic cancer

  Saltzman DA, Kavan P, Augustin L, Schottel J, Lee JT, Moradian J, Moradian E, Batist G. Cancer Immunology, Immunotherapy. 2026;75:307.

  Cancer Immunology, Immunotherapy
• 2026

  Live Biotherapeutic Salmonella-IL2 (Saltikva) Plus FOLFIRINOX for Stage IV Metastatic Pancreatic Ductal Adenocarcinoma – Implications of a Phase 2 Clinical Trial

  Saltzman DA, Kavan P, Augustin L, Schottel J, Lee JT, Moradian J, Moradian E, Batist G. Journal of Cellular Immunology. 2026;8(2):37–47.

  Journal of Cellular Immunology
• 2026

  Suppression of New Metastases with Saltikva in a Phase II Clinical Trial: A Potential Signal of Immune Memory in Metastatic Pancreatic Ductal Adenocarcinoma

  Batist G, Moradian J, Moradian E, Saltzman DA. Journal of Cellular Immunology. 2026;8(2):48–52.

  Journal of Cellular Immunology
• 2025

  Influence of Salmonella-IL2 in combination with FOLFIRINOX on overall and progression-free survival in stage IV metastatic pancreatic cancer

  Saltzman D, Kavan P, Augustin L, Schottel J, Lee JT, Moradian J, Moradian E, Batist G. Journal of Clinical Oncology. 2025;43(16_suppl):2571 (ASCO Annual Meeting).

  Journal of Clinical Oncology (ASCO)
• 2023

  Abstract CT035: Addition of Salmonella-IL2 to FOLFIRINOX for metastatic stage 4 pancreatic cancer nearly doubles median survival

  Kavan P, Saltzman D, Moradian J, Muegge J, Batist G. Cancer Research. 2023;83(8_Suppl):CT035 (AACR Annual Meeting).

  Cancer Research (AACR)
• 2020

  Orally Administered Multiple Dose Saltikva (Salmonella-IL2) in Conjunction with FOLFIRINOX in a Patient with Stage IV Pancreatic Cancer: A Case Report

  Batist G, Park J, et al. Clinical Oncology: Case Reports. 2020.

  Clinical Oncology: Case Reports
• 2018

  White paper on microbial anti-cancer therapy and prevention

  Forbes NS, Coffin RS, Deng L, … Moradian E, … Saltzman DA, et al. Journal for ImmunoTherapy of Cancer. 2018;6:78.

  Journal for ImmunoTherapy of Cancer
• 2016

  A phase I clinical study to evaluate safety of orally administered, genetically engineered Salmonella enterica serovar Typhimurium for canine osteosarcoma

  Fritz SE, Henson MS, Greengard E, … Modiano JF, Saltzman DA. Veterinary Medicine and Science. 2016;2(3):188–198.

  Veterinary Medicine and Science
• 2015

  Attenuated Salmonella enterica Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer Model

  Drees JJ, Mertensotto MJ, Liu G, Panyam J, Leonard AS, Augustin LB, Schottel JL, Saltzman DA. Anticancer Research. 2015;35(2):843–850.

  Anticancer Research
• 2011

  Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepatic metastasis

  Sorenson BS, Banton KL, Augustin LB, Leonard AS, Saltzman DA. OncoTargets and Therapy. 2011;4:53–61.

  OncoTargets and Therapy
• 2010

  Safety and immunogenicity of Salmonella typhimurium expressing C-terminal truncated human IL-2 in a murine model

  Sorenson BS, Banton KL, Frykman NL, Leonard AS, Saltzman DA. Biologics: Targets & Therapy. 2010;4:61–73.

  Biologics: Targets & Therapy
• 2008

  Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma

  Sorenson BS, Banton KL, Frykman NL, Leonard AS, Saltzman DA. Clinical Orthopaedics and Related Research. 2008;466(6):1285–1291.

  Clinical Orthopaedics and Related Research
• 2008

  Attenuated Salmonella typhimurium with interleukin 2 gene prevents the establishment of pulmonary metastases in a model of osteosarcoma

  Sorenson BS, Banton KL, Frykman NL, Leonard AS, Saltzman DA. Journal of Pediatric Surgery. 2008;43(6):1153–1158.

  Journal of Pediatric Surgery
• 2003

  Attenuated Salmonella typhimurium prevents the establishment of unresectable hepatic metastases and improves survival in a murine model

  Soto LJ III, Sorenson BS, Kim AS, Feltis BA, Leonard AS, Saltzman DA. Journal of Pediatric Surgery. 2003;38(7):1075–1081.

  Journal of Pediatric Surgery
• 2002

  Liver and Circulating NK1.1⁺CD3⁻ Cells Are Increased in Infection with Attenuated Salmonella typhimurium and Are Associated with Reduced Tumor in Murine Liver Cancer

  Feltis BA, Miller JS, Sahar DA, Kim AS, Saltzman DA, Leonard AS, Wells CL, Sielaff TD. Journal of Surgical Research. 2002;107(1):101–107.

  Journal of Surgical Research
• 2002

  Cyclooxygenase-2 Inhibition Augments the Hepatic Antitumor Effect of Oral Salmonella Typhimurium in a Model of Mouse Metastatic Colon Cancer

  Feltis BA, Sahar DA, Kim AS, Saltzman DA, Leonard AS, Sielaff TD. Journal of Gastrointestinal Surgery. 2002.

  Journal of Gastrointestinal Surgery
• 1996

  Antitumor mechanisms of attenuated Salmonella typhimurium containing the gene for human interleukin-2: A novel antitumor agent?

  Saltzman DA, Katsanis E, Heise CP, Hasz DE, Vigdorovich V, Kelly SM, Curtiss R III, Leonard AS, Anderson PM. Journal of Pediatric Surgery. 1996;31(2):301–306.

  Journal of Pediatric Surgery
• 1996

  Attenuated Salmonella typhimurium containing interleukin-2 decreases MC-38 hepatic metastases: A novel anti-tumor agent

  Saltzman DA, Heise CP, Hasz DE, Zebede M, Kelly SM, Curtiss R III, Leonard AS, Anderson PM. Cancer Biotherapy & Radiopharmaceuticals. 1996;11(2):145–153.

  Cancer Biotherapy & Radiopharmaceuticals

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